Formation of Secondary Osteoporosis and Osteopenia in Patients with Chronic Gastritis and Duodenal Ulcer
Relevance. The problem of osteoporosis today has gone far beyond the scope of clinical medicine, which sometimes defines this circumstance as a social problem. The development of disorders of bone mineral density in such common diseases of the gastrointestinal tract as chronic gastritis and duodenal ulcer is not sufficiently covered in the medical literature.
Purpose of research. Study of the role and significance of etiological and pathogenetic factors of chronic gastritis and peptic ulcer disease in the pathogenesis of secondary osteoporosis and osteopenia.
Materials and methods of research. Clinical, biochemical, immunological, and instrumental studies were conducted in 64 patients with chronic gastritis and duodenal ulcer, aged 19 to 45 years (21 women and 43 men). Of these, 34 patients were diagnosed with duodenal ulcer and 30 with chronic antral HP associated type B gastritis, within two years.
Results. In all patients with chronic gastritis and duodenal ulcer included in the study, the conducted respiratory test for HP was positive. the studies conducted in this section showed different diagnostic value of determining the parameters of BMD in gastrointestinal diseases. In patients with chronic gastritis and duodenal ulcer the concentrations of calcium and phosphorus, the activity of alkaline phosphatase in serum did not change. Violations of BMD indicators are reliably reflected in the indicators of b-cross laps and oxyproline. For chronic gastritis and duodenal ulcer is accompanied by a violation of the BMD indices due to the activation osteodystrophies processes.
Conclusion. The formation of secondary osteopenia in chronic gastritis and duodenal ulcer occur mainly by activating the processes of bone resorption and with the participation of hyperproduction of pro inflammatory cytokines IL-6 and TNFα, an imbalance in the POL-AOZ system, initiated by a Helicobacter infection in the gastric mucosa and hypergastrinemia.