In vitro antibacterial and anticancer response of MgO nanoparticles prepared by solution combustion synthesis

Abstract

In the present work, solution combustion synthesis of MgO using lemon juice and citric acid as fuels has been carried out. A comparative analysis of the obtained samples has been conducted to understand the strategic advantages of using lemon juice over citric acid as the combustion fuel for the synthesis of MgO nanoparticles. Antibacterial studies were carried out against Escherichia coli and Staphylococcus aureus by well diffusion method. Minimum inhibitory concentration was determined by micro broth dilution technique. Anticancer activity of MgO NPs was tested against MDA MB-231 and HeLa cell lines by 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay. Haemolysis assay was performed to evaluate the biocompatibility of MgO NPs.