A Mathematical study of Enterohepatic Circulation of Drugs with Time Delay in Two Compartment Model

Abstract

A study is projected to explain the pharmacokinetics of drug with oral administration focused to enterohepatic circulation with time delay. An analytic solution is obtained for a model to be considered as a scheme of two non-linear differential equations using Laplace Transforms. The plasma level profiles are obtained by the computer simulation which is leading to rebound and secondary peaks.