Synthesis, Characterization, Docking studies, Evaluation of Thiazinyl-thiazolidinone derivatives as potential in vitro antidiabetic and antioxidant agents.

  • Ramarajan Rajalakshmi , Rajavel Santhi, Thangaraj Elakkiya

Abstract

A new series of thiazinyl-thiazolidinone synthesized by reacting involving condensation of aromatic aldehyde and ketone yields the corresponding chalcone. Amino thiazine is expected to form by reaction involving thiourea with chalcone in basic medium. Amino thiazine condenses with aldehyde yields the corresponding Schiff bases. Finally the Schiff bases reaction involving with thioglycolic acid in presence of zinc chloride catalyst to give the thiazolidinone derivatives. All the synthesized compounds were evaluated by FT-IR and 1H NMR spectroscopic techniques. All the compounds were tested in vitro antidiabetic and antioxidant activity. Molecular docking studies were carried out 2HR7 protein.

Published
2020-04-30
How to Cite
Ramarajan Rajalakshmi , Rajavel Santhi, Thangaraj Elakkiya. (2020). Synthesis, Characterization, Docking studies, Evaluation of Thiazinyl-thiazolidinone derivatives as potential in vitro antidiabetic and antioxidant agents. International Journal of Advanced Science and Technology, 29(08), 6091 - 6103. Retrieved from https://sersc.org/journals/index.php/IJAST/article/view/33863
Section
Articles