FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATIRX TABLET OF VILDAGLIPTIN USING NATURAL AND SYNTHETIC POLYMERS
The aim of this paper was to evulate vidagliptin matrix tablet of 50 mg. Vildagliptin is an anti diabetic drug of new dipeptidylpeptidase – 4 (DPP-4) inhibitor class of drug Vildagliptin is one of the best passed relefing and short acting drug. Medication is developed in such a way that will provide the full advantage of SR formulations. The natural polymer like pectin was utilized in the formulation of the matrix tablet with the help of wet granulation technique we can find out the characteristics and evaluation of drug containing vildagliptin. Pectin is one of the hydrophilic polymer was utilized in the formulation of these tablets and all the formulation showed the pharmacopeian standard. There are six different types of formulation of drugs with polymer concentration, first three drugs contain pectin polysaccharide and the other three contain polymers combination of pectin HPMC K100M- F1 (1:1), F2 (1:2), F3 (1:3) F4 (1:1), F5 (1:2) and F6 (1:3). Some all the above formulation F6 is the best and show best result up to 12 hrs. It is also absorbed that F6 with pectin combination shows better sustain effect. These result shows that drug release kinetic was absorbed by increasing their polymer concentration. The data which was collected was fitted to various models (mathematical model) like higuchi, first- order and zero order, to find out the mechanism of drug release. F6 shows higuchi model. So the present study evaluate the drug release (vitro) by interchanging are changing the amount of polymer according to patient compliance and improvement.