Analytical Applications of in-situ Generated Potassium Trithiocarbonate in DMSO: Determination of Tetraethyl Thiuram Disulfide in Commercial Drugs.
A simple and rapid method has been described for determination of tetraethyl thiuram disulfide in commercial drug formulations with Potassium trithiocarbonate (K2CS3). The reagent is generated in-situ in dimethly sulphoxide (DMSO) quantitatively by just adding 3-4 drops of carbon disulfide to a known amount of potassium hydroxide. The determination has been carried out visually (to the appearance of red colour), potentiometrically (using Pt - SCE assembly) and photometrically (440 nm being analytical wavelength). The method has successfully been applied to the assay of Antabuse tablets containing tetraethyl thiuram disulfide.
Keywords: Potassium trithiocarbonat; Dimethylsulphoxide (DMSO); tetraethyl thiuram disulfide; Antabuse tablets.