Analytical Applications of in-situ Generated Potassium Trithiocarbonate in DMSO: Determination of Tetraethyl Thiuram Disulfide in Commercial Drugs.

  • Jasvir Singh

Abstract

A simple and rapid method has been described for determination of tetraethyl thiuram disulfide in commercial drug formulations with Potassium trithiocarbonate (K2CS3).  The reagent is generated in-situ in dimethly sulphoxide (DMSO) quantitatively by just adding 3-4 drops of carbon disulfide to a known amount of potassium hydroxide. The determination has been carried out visually (to the appearance of red colour), potentiometrically (using Pt - SCE assembly) and photometrically (440 nm being analytical wavelength).  The method has successfully been applied to the assay of Antabuse tablets containing tetraethyl thiuram disulfide.

 Keywords: Potassium trithiocarbonat; Dimethylsulphoxide (DMSO); tetraethyl thiuram disulfide; Antabuse tablets.

Published
2019-12-19
How to Cite
Singh, J. (2019). Analytical Applications of in-situ Generated Potassium Trithiocarbonate in DMSO: Determination of Tetraethyl Thiuram Disulfide in Commercial Drugs. International Journal of Advanced Science and Technology, 28(16), 1631 -. Retrieved from https://sersc.org/journals/index.php/IJAST/article/view/2151
Section
Articles