THE TOXICITY OF GOLD NANOPARTICLES ON LIVER FUNCTION OF ALBINO MICE

  • Zainab Ahmad Hassan, Hind Hussein Obaid,Mustafa Nuhad al-Darraji

Abstract

The gold nanoparticles produced in an eco-friendly green method were made using soaked orange peels
(citrus Sinensis) as a reducing agent. The gold nanoparticles were diagnosed using the approved
methods, including the transmission electron microscope and the visible UV spectroscopy. Thus, the
results of the diagnosis showed the formation of spherical particles with a size of 36 nanometers. Their
biological effects on the liver function of albino mice were studied.
Male albino mice were used in this study and randomly divided into seven groups. The first group was
the control group injected with the physiological solution (Normal Saline) and the other six groups
were injected with different doses of the solution of the gold nanoparticles (1, 2, 4, 6, 8 and 10) Mg /
kg. The effect of gold nanoparticles on liver function was measured by measuring the level of liver
enzymes (GPT) Glutamate-Pyruvate Transaminase and (GOT) Glutamate Oxalic Transaminase and
Alkaline Phosphatase (ALP) in serum. Results for GPT examination showed a significant decrease
(P≤0.01) for the two doses 8 and 10 mg / kg and did not show any significant effect for the rest of the
doses. Also, the GOT test showed a significant decrease (P≤0.01) in the low doses 1 and 2 mg / kg and
in high doses 8 and 10 mg / kg, as well as increased significantly in concentrations 4 and 6 mg / kg.
However, the ALP examination recorded a significant increase (P≤0.01) in the dose of 6 mg / kg, a
significant decrease (P≤0.01) for doses 8 and 10 mg / kg and no significant difference (P> 0.01) for the
rest of the doses.

Published
2020-04-13
How to Cite
Zainab Ahmad Hassan, Hind Hussein Obaid,Mustafa Nuhad al-Darraji. (2020). THE TOXICITY OF GOLD NANOPARTICLES ON LIVER FUNCTION OF ALBINO MICE. International Journal of Advanced Science and Technology, 29(9s), 542-548. Retrieved from https://sersc.org/journals/index.php/IJAST/article/view/13132