Evaluation Of Contraceptive Efficacy Of Ethanolic Extract Of Lygodium Flexuosum In Male Albino Rat: A Histological Approach

Abstract

 Lygodium Flexuosum Has Been Used In The Various Traditional And Modern Medicines As It Has Many Ethnobotanical Aspects. The Present Investigation Deals With Contraceptive Efficacy Of Lygodium Flexuosum With Its Ethanolic Extract On The Male Albino Rat Against Control. The Investigation Involves The Oral Administration Of Sexually Matured Fertile Male Albino Rat With An Ethanolic Extract Of Lygodium Flexuosum At The Dose Regimen Of 100 Mg/Kg B. Wt. /Rat For 60 Days As An Experimental Group Whereas Control Group Has Received Vehicle Only Wherein Both The Groups Has 6 Animals Each. Rats Were Castrated For The Histopathological Investigations Where Tissues Were Fixed In The Bouin’s Fixative, Dehydrated, Sectioned And Stained With Hematoxylin And Eosin. Treatment Of Lygodium Flexuosum In An Experimental Group Have Shown Degenerated Germinal Epithelium Lining Of Seminiferous Tubule With Spermatocytes, And Spermatozoon Debris In The Lumen And Tubules Along With Disoriented Acini, Shrunken Cells With Stromal And Cellular Degeneration In Prostate, Degenerative Changes And Reduced Secretion In Seminal Vesicle, Spermatozoan Debris, Degenerating Epithelial Layer, Reduction In The Lumen Size Of Cauda Epididymis, Degenerating Epithelial Lining And Distinctly Visible Spermatogonial Debris In The Lumen Of Caput Epididymis. Also Spermatozoon Debris, Reduction In Lumen Size Of Vas Deferens Was Noted. The Entire Study Was Conducted By Following The Rules And Regulation Of Cpcsea At Agharkar Reseach Institute, Pune.