Synthesis, Characterization and Biological Activity Studies of Mixed Ligand Complexes of Copper with Paracetamol and Amino Acids
Synthesis of mixed ligand copper (ll) complexes of type [M(par)(L)].2H2O have been carried out by using Paracetamol (par) as a primary ligand and Amino acid (HL) such as L-Valine, L-Threonine and L-Serine as a secondary ligand. The metal complexes so synthesized have been characterized on the basis of elemental analysis, electrical conductance, room temperature magnetic susceptibility measurement and spectral analysis which include UV, IR and XRD techniques. An electrical conductance studies indicates non-electrolyte nature and magnetic susceptibility measurement revealed paramagnetic nature of the complexes. UV spectra shows intra-ligand, charge transfer and d-d transition and IR spectra confirm bonding of metal ion through O or N donar ligands which further indicates complexation. The agar cup method and tube dilution method have been used to study antibacterial activity of the complexes against pathogenic bacteria such as S.Aureus, C.Diphtheriae, S.Typhi and E.Coli.