Preparation and Spectral Studies of Biologically Active Mixed Ligand Cerium (III) Complexes

Abstract

Cerium (III) complexes of type [M (Q) (L).H₂O] have been prepared by using 8-hydroxy quinoline (HQ) as a primary Ligand and amino acids (HL) such as secondary ligands. The mixed ligand metal complexes have been studied spectrochemically and characterized by elemental analysis. Room temperature magnetic susceptibility measurement specifies that cerium (III) complexes are paramagnetic in nature. Electrical conductance studies of the complexes indicate their non-electrolytic nature. Electronic Absorption spectra of the complexes shows intra ligand, charge transfer and d-d transitions respectively. The thermal analysis data of the complexes indicates the presence of coordinated water molecules. FTIR spectra show bonding of the metal ion through N- and O- donor atoms of the ligand molecules. Tube dilution and agar cup methods were implemented for the study of antibacterial activity of the complexes against S.aureus, C.diphtheriae, S.typhi and P.auruginosa. The antibacterial activity of the prepared complexes have been determined by using tetracyclin as standard antibacterial compound and it was found that, the complexes show mild activity against selected stains of micro-organisms as compared to standard tetracycline.