Design, Synthesis and Anti-microbial Study of 6-amino-N-substtituted-benzo[d]thiazole-2-sulfonamide Derivatives

Abstract

A new series of novel 6-amino-N-substtituted-benzo[d]thiazole-2-sulfonamide derivatives (5a-5j) ware designed and synthesized from commercially available 6-nitrobenzo[d]thiazol-2-amine. The compounds ware synthesized through a series of reactions involving sulfonation, sulfonamide coupling and reduction. All the steps are optimized for getting better yields and clean reaction profile. The synthetic compounds ware characterized by analytical techniques like ¹H NMR, ¹³C NMR, LCMS and IR. All the synthetic derivatives are evaluated for their antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtillis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity. The compounds 5d, 5e and 5g showed promising inhibitions for most of antimicrobial strains. The results of antimicrobial screening data revealed most of compounds showed moderate to promising microbial inhibitions.