Synthesis, Characterization And Biocompatibility Of Chitosan Functionalized Nanocarrier For Controlled And Curing Of Cancer Cells

  • Sivalingam Lakshmanan


This study reports the in vitro cytotoxic effect of Curcumin (CR)-loaded chitosan (CS)-cross-linked polybutylene glycol (PBG) nanocarriers. The nanocarriers were prepared by ion gelation using barium chloride (BaCl2), calcium oxalate (Ca(COO)2), and sodium tripolyphospate (TPP) as cross-linking agents. The influence of the cross-linking agent on the size and morphology of the CS-PBG nanocarriers was studied by dynamic light scattering (DLS) and scanning electron microscope (SEM). TPP assisted carriers was found higher amount CR encapsulation capacity compared with other two carriers. The drug releasing behavior was studied at pH 6.8 which was based on the bulk erosion principle of the carriers. CR loaded CS-PBG carriers were found to show excellent drug releasing kinetics and biocompatibility in in-vitro analysis.