Pharmacological studies of Polyherbal capsules using acute toxicity studies

Abstract

Nowadays, herbal drugs represent a major component not only in traditional medicine and health care systems but also in the nutraceuticals and cosmetics industry. One-quarter of the medical prescriptions are formulations based on substances derived from plants or plant-derived synthetic analogs. Above all, it is believed that drugs derived from medicinal plants have added advantage of being simple, effective, and offering a broad spectrum of activities with an emphasis on preventive action.

Acute Toxicity studies of Coded 4-Plus Capsules on Wistar rats were carried out and found that the administration single dose of 4-Plus capsules up to a concentration of 5 g/kg.b.wt did not produce any mortality and did not produce any toxicity to rats at a concentration (up to 5g/kg) and time studied (14 days).Administration of 4-Plus (a Poly Herbal formulation (100 mg/kg/b.wt, 200 mg/kg//b.wt, 300 mg/kg//b.wt) increased the clearance of carbon particles from blood as indicated by a significant increase in the phagocytic index (p<0.05) when compared with the control group.