Development and Evaluation of Transdermal Drug Delivery System of Lorazepam

Abstract

Lorazepam is an anticonvulsant drug with poor drug release rate. For Improving the release rate of lorazepam through skin it is loaded as transdermal patch were the films was developed by using chitosan, propylene glycol, glycerin, sodium Triphosphate (TPP). Propylene glycol is used as a Plasticizer. Drug excipents compatibilities study was confirmed by differential scanning Colorimetry. The transdermal film was prepared by solvent evaporation technique and the aqueous phase was sonicated by ultrasonication at a constant temperature, and above the melting point. The transdermal films were characterized for thicknesses, moisture content, mechanical strength, drug content, FTIR, X-ray diffraction and microscopy. In vitro release studies were performed in Keshary-chein diffusion cell apparatus. The result shows that the skin has best release characteristics from of the chitosan films