Exploitation Of Limonia Acidissima Linn. Gum As A Novel Natural Binding Agent In The Designing Of Tablet Formulations

Abstract

The development of new excipients for potential use as binding agent in tablet formulations continues to be of interest. Natural gums were widely used in the pharmaceutical and food industry as excipients and additives due to their low toxicity, biodegradability, plentiful availability and low cost. This study was undertaken to explore Limonia Acidissima Linn. gum (LAG) as a binding agent in various concentrations like 2%, 4%, 6%, 8%, 10% etc. in formulation of Diclofenac sodium Tablets. The prepared granules were characterized to assess the flow and compression properties and when compressed, all the compendial and non-compendial tests were performed to assess the tablet properties with Limonia Acidissima Linn. gum in comparison with those prepared with starch as a standard binder. Granules prepared with Limonia Acidissima Linn. gum exhibited good flow properties with angle of repose, Carr’s index and Hausner’s quotient. The physical properties of the tablets containing the LAG showed the sufficient hardness, low friability and desirable disintegration time & comparable drug release as compared to formulation containing starch as standard binder.