Formulation And Development Of Novel Gel Of Glabridin And Its HPLC Analysis

Abstract

The aim of the present investigation was to design an appropriate form of glabridin, using vesicular delivery system. Transfersomes were prepared by film hydration method and characterized by Entrapment efficiency, Infrared spectroscopy and Scanning electron microscopy. In-vitro diffusion studies of gel formulation were performed. Prepared Transfersome were predominantly brownish and spherical in shape. The infrared spectra revealed the absence of drug excipients interaction. Scanning electron microscopy and deformability studies confirmed spherical and deformable nature. In-vitro release studies and stability studies shown appropriate results indicate that the glabridin loaded transfersomal gel would be efficacious in treating various hyperpigmentation disorders.