Synthesis And Characterisation Of Carboxymethyl Sesbania Galactamannan Seed Gum For Pharmaceutical Application

Abstract

Recent studies focus on the chemical modification of polysaccharides for pharmaceutical
applications. The gum is derived from the endosperm of seeds of the plant Sesbania Grandiflora
(Leguminosae). The modifications here discussed include the introduction of carboxymethyl groups
into the molecule in variety of conditions, for extending the applications of partially
carboxymethylated sesbania gum. Variables studied include weight of the etherifying agents, alkaline
volume & concentration and preparation medium like temperature. Modification increases the
solubility, stability and viscosity of the unmodified gum, which was increased by increasing the
degree of substitution (DS). DS increase with concentration of etherifying agent, alkali and
temperature increase. Resultant product was characterised by using FTIR, DSC, XRD, SEM,
rheological properties, solubility, swelling and gel fraction study. The carboxymethylated sesbania
gum alternative approach for to improve the interface between chitosan and hydroxyapatite which is
useful for the bone repairing and CMS form a composite in chitosan and hydroxyapatite these
approach were in process.