Synthesis, Characterization, Docking studies, Evaluation of Thiazinyl-thiazolidinone derivatives as potential in vitro antidiabetic and antioxidant agents.

Abstract

A new series of thiazinyl-thiazolidinone synthesized by reacting involving condensation of aromatic aldehyde and ketone yields the corresponding chalcone. Amino thiazine is expected to form by reaction involving thiourea with chalcone in basic medium. Amino thiazine condenses with aldehyde yields the corresponding Schiff bases. Finally the Schiff bases reaction involving with thioglycolic acid in presence of zinc chloride catalyst to give the thiazolidinone derivatives. All the synthesized compounds were evaluated by FT-IR and ¹H NMR spectroscopic techniques. All the compounds were tested in vitro antidiabetic and antioxidant activity. Molecular docking studies were carried out 2HR7 protein.