Biological Evaluation Of Synthesized Trsubstituted 1, 3, 5 Triazine Derivatives For Anti Bacterial Activity

Abstract

During the course of study, varyingly substituted 1,3,5-triazines were synthesized and screened for their antibacterial activity. It obvious from Structure Activity Profile that, antibacterial activity of these tri-substituted triazines is associated with their individual triazine nucleus as well as the phenyl thiazole motifs in their hybrid structure. The 1,3,5-triazine ring is a very versatile entity that is able to take part in H-bonds, coordination with metals and π-interactions to form remarkable supramolecular structures in which s-triazine acts as an acceptor.  Biological data revealed that all the synthesised compounds have significant activity against tested strains of bacteria. Compound LC13 found most active against gram-ve (Escherichia coli and Pseudomonas aeruginosa) where as LC19 found most active against gram +ve (Bacillus subtilis and Staphylococcus aureus).