Indicators Of Mineral Density Of Bone Tissue And Levels Of Calciotropic Hormones In Children And Adolescents With Thyroetoxicosis

Abstract

Introduction. In childhood and adolescence, a genetically determined bone mass accumulates,
which ensures the strength of the skeleton throughout life. But with thyrotoxicosis, a separation of the
processes of bone resorption and synthesis and the formation of sites of osteoporosis and osteosclerosis
occur, leading to the loss of 10% of bone mass in 1 cycle of remodeling. Because of the lack of
information about this phenomenon, our work aimed to study the state of bone mineral density and
levels of calciotropic hormones in children and adolescents with thyrotoxicosis.
Materials and Methods. The study was conducted by 33 children and adolescents with
thyrotoxicosis. The control group consisted of 23 healthy children and adolescents. All studies were
conducted in the RSSPMCE. Thyroid status, PTH and vitamin D were determined using a closed-type
immunochemistry analyser Cobas e 411 Hitachi company HoffmanLeRoche (Switzerland) and its
reagents. Bone mineral density was evaluated by dual-energy absorptiometry on a Stratos X-ray
densitometer from DMS, France.
Results and Discussion. The results of the study showed that the average value of the level of
vitamin D in the group with thyrotoxicosis was 9.8 ± 1.1 ng / ml, against 20.4 ± 6.2 ng / ml of the control
group, while its deficiency was diagnosed in 87.8%, and its insufficiency - in 12.2% of pediatric patients.
In the group with thyrotoxicosis, the average level of PTH was lower and completed to 45.1 ±
4.9 ng / ml (p <0.05) compared with the control (49.2 ± 4.3 ng / ml); hypoparathyroidism was found in
6.3 times more often than among healthy children, and 24.2% showed an increase in the level of PTH.
In children and adolescents with thyrotoxicosis Z- index of the femoral neck, lumbar vertebrae and the
general body were significantly lower than in the control group. 63.6% of children with thyrotoxicosis
have osteoporosis, 24.2% - osteopenia.