State Of The Immune System In Patients With Hospital Pneumonia In The Background Of Chronic Kidney Disease
Abstract
Objective: to study some indicators of the immunohemogram in patients with communityacquired pneumonia on the background of CKD.
Materials and methods. 120 patients with community-acquired pneumonia were examined: 40
patients with pneumonia (group Pn) and 80 pneumonia, which developed against the background of
chronic kidney disease (group Pn+ CKD). The control group (CG) consisted of 20 healthy people. The
study found that the number of leukocytes was increased in the Mon + CKD group by 162.24% than in
the CG (p <0.001), in the Mon group 263.14% higher than in the CG and 27.79% than in the group
Mon + CKD (p <0.001). In patients with Mon, the ratio of the number of neutrophils to lymphocytes
significantly increased (p <0.001 compared with the CG and the Mon + CKD group), reflecting the
shift of the formula to the left, and in the Mon + CKD group this ratio remained unchanged, despite the
increase in the absolute number of leukocytes. In patients with pneumonia with background CKD, a
marked increase in T-lymphocytes was observed due to a subpopulation of CD8 and CD95 cells (p
<0.001 compared with CG and the Mon group). An increase in IgM concentration prevailed in the
pneumonia group, and an increase in IgG prevailed in the PN + CKD group (p <0.001).
Conclusion. Pneumonia associated with CKD is associated with an overactive systemic
inflammatory response involving non-specific immunity and the depletion of its cellular component, as
well as activation of acquired immunity due to chronic inflammation and chronic antigenic stimulation.