State Of The Immune System In Patients With Hospital Pneumonia In The Background Of Chronic Kidney Disease

  • Daminov Botir Turgunpulatovich, Daminova Lola Turgunpulatovna, Asadov Nodirjon Zakirovich, Muminov Davron Kadirovich

Abstract

Objective: to study some indicators of the immunohemogram in patients with communityacquired pneumonia on the background of CKD.
Materials and methods. 120 patients with community-acquired pneumonia were examined: 40
patients with pneumonia (group Pn) and 80 pneumonia, which developed against the background of
chronic kidney disease (group Pn+ CKD). The control group (CG) consisted of 20 healthy people. The
study found that the number of leukocytes was increased in the Mon + CKD group by 162.24% than in
the CG (p <0.001), in the Mon group 263.14% higher than in the CG and 27.79% than in the group
Mon + CKD (p <0.001). In patients with Mon, the ratio of the number of neutrophils to lymphocytes
significantly increased (p <0.001 compared with the CG and the Mon + CKD group), reflecting the
shift of the formula to the left, and in the Mon + CKD group this ratio remained unchanged, despite the
increase in the absolute number of leukocytes. In patients with pneumonia with background CKD, a
marked increase in T-lymphocytes was observed due to a subpopulation of CD8 and CD95 cells (p
<0.001 compared with CG and the Mon group). An increase in IgM concentration prevailed in the
pneumonia group, and an increase in IgG prevailed in the PN + CKD group (p <0.001).
Conclusion. Pneumonia associated with CKD is associated with an overactive systemic
inflammatory response involving non-specific immunity and the depletion of its cellular component, as
well as activation of acquired immunity due to chronic inflammation and chronic antigenic stimulation.

Published
2020-06-01
How to Cite
Daminov Botir Turgunpulatovich, Daminova Lola Turgunpulatovna, Asadov Nodirjon Zakirovich, Muminov Davron Kadirovich. (2020). State Of The Immune System In Patients With Hospital Pneumonia In The Background Of Chronic Kidney Disease. International Journal of Advanced Science and Technology, 29(7), 9554-9557. Retrieved from http://sersc.org/journals/index.php/IJAST/article/view/26453
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Articles