Genetic Polymorphism Of The System Of Natriuretic Peptides And LongTerm Results Of Coronary Artery Stenting

Abstract

The aim of the study was to determine the effect of genetic polymorphism on the effects of
endovascular revascularization in patients with coronary artery disease, angina pectoris FC III-IV
Materials methods. The study included 158 patients with coronary heart disease with angina
pectoris of FC III-IV tension (women 34 - 21.52%). Upon inclusion in the study, all patients underwent:
Echocardiography, TLC, genotyping of 6 genes of the system of natriuretic peptides, coronary
angiography and stenting of the coronary arteries. For follow-up examination, patients were invited
after a year. The study included echocardiography, TLC, stress echocardiography.
Results. Genetic analysis allows predicting the long-term effect of coronary artery stenting: the
relative risk of coronary heart disease progression (in the form of stress-induced ischemia) in patients
with minor alleles is 2.12 times higher than in patients with dominant homozygotes for genes of the
natriuretic peptide system.
Conclusion. The present study found that the presence of minor alleles of genes of the system
of natriuretic peptides is associated with a greater prevalence of atherosclerotic lesions of the coronary
bed, the activity of structural and functional remodeling of the heart. In addition, the presence of minor
alleles reduces the long-term effectiveness of coronary revascularization, both in the aspect of coronary
atherosclerosis and in the aspect of the functional state of the myocardium (progression of LV dilatation
and preservation of the hibernating myocardium).