Microwave-Assisted Synthesis of 6-ARYL[1,8] NAPHTHYRIDINO [1’,2’:1, 2]IMIDAZO[4,5-b]PHENAZINES

Abstract

A simple  and efficient method  for the synthesis of novel 6-aryl [1,8] naphthyridino [1’,2’:1,2] imidazo [4,5-b] phenazines 3 by the cyclocondensation of 3-aryl-2-chloro-1,8-naphthyridines 1  with  2,3-diaminophenazine 2  in  the presence of a catalytic amount of DMF in solvent-free conditions under microwave irradiation is described. The products are obtained in very good yields and excellent purities. The structures of the compounds 3 were determined by their analytical and spectral (IR, ¹H NMR and MS) data. The compounds 3 have been evaluated for their antibacterial activity.