Solvent-Free Synthesis of 2,9-DI(3-ARYL[1,8]NAPHTHYRIDIN-2-YL)-1,2,3,4,7,8,9,10-OCTAHYDRO [1,2] DIAZEPINO[4’,5’:4,5] NAPHTHO[1,8-DE][1,2]DIAZEPINE-1,4,7,10-Tetraones using Non-Traditional Conditions

Abstract

Efficient and eco-friendly synthesis of 2,9-di(3-aryl[1,8]naphthyridin-2-yl)-1,2,3,4,7,8,9,10-octahydro[1,2]diazepino[4’,5’:4,5]naphtho[1,8-de][1,2]diazepine-1,4,7,10-tetraones  3  is reported by  the cyclocondensation of 3-aryl-2-hydrazino-1,8-naphthyridines 1 with 1,4,5,8-naphthalene tetracarboxylic diandydride 2 in 2:1 molar ratio  in the presence of catalytic amount of DMF in combination with microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions.  The products are obtained in very good yields with high purity. The structures of the compounds 3 were determined by spectral (IR, ¹H NMR and MS) and analytical data. The compounds 3 have been evaluated for their antibacterial and anti-inflammatory activities.