Enantioselective Alkynylation of some Cyclical Ketones by 3,3′-Diphenylbinaphtol Dilithium

Abstract

Process of enantioselective alkynylation of some cyclical ketones – cyclohexanon,
2-methylcyclohexanon, menton and camphora by 3,3′-diphenylbinaphtol dilithium has been investigated and mechanism of it’s carring out has been proposed. Influence of quantity of catalyst on the yield of product was investigated. Purity and structure of synthesised alcohols such as 1-(2-phenylethynil) cyclohexanol, 2-methyl-1-(2-phenylethynil) cyclohexanol, 2-isopropyl-5-methyl-1-(2-phenylethynil) cyclohexanol and 1,7,7-threemethyl-2-(2-phenylethynil) biciclo[2,2,1]-heptanol-2 have been determined by different physico-chemical methods.