FORMULATION AND EVALUATION OF FLOATING TABLET OF ZOLMITRIPTAN TABLET
Abstract
The present investigation was performed to find out floating tablets of Zolmitriptan tablet by wet granulation method. Zolmitriptan in floating tablets by using various Viscosity grades of Hydroxy Propyl Methyl Cellulose, HPMC K15 M and Ethyl cellulose. The Sodium bicarbonate also added in different concentrations as an agent of gas generating to improve floating capacity of tablet. All the tablets were studied for their parameters for Pre-compression Bulk density, Tapped density, Carr’s index, Hausner’s ratio and Angle of repose and Post-compression Hardness, Thickness, Friability, Weight variation and Content uniformity. Tablets are also evaluated in-vitro shows best release range of 12 hours. The release kinetics of some formulation like F2, 3, 4, 5 and 9 followed Higuchi model, formulation F1, 5, 6, 7 and 8 followed the Zero order and formulation F1 and 5 followed 1st-order. There is no change in colour, but change in Hardness, occur in evaluation of formulation 4. Various studies were taken place (in-vitro) which increase the gastric residence time and improved bioavailability of the drug. Hence in the present investigation floating tablets have been synthesized to overcome drawbacks associated with Antimigraine tablet of Zolmitriptan.
