Continuous Sorting Of Shigatoxin- E. Coli (Stec) Using I-Shaped Pillar Arrays In A Microfluidic Device

Abstract

To do better diagnosis and detection of infectious diseases in the least possible time, we need to isolate and collect the biological entities like pathogenic bacteria from the given sample medium. The advances in the microscale technology have resulted in developing microfluidic devices where the bioparticles separation happens at the micro-level. These devices require a minimal amount of sample for the process and give highly précised and accurate results within less amount of time. This paper discusses the design and simulation of the microfluidic device using COMSOL Multiphysics 5.5 for the separation of the Shiga toxin-producing Escherichia Coli shaped particle which is mainly non-spherical in shape using arrays of modified I – shaped pillars from the given sample. This work also focuses on the geometrical aspects of the micropillar in an array to ensure that maximum throughput while separating the non-spherical particles.