Serum Procalcitonin (Pct) As A Promising Marker For Making Diagnostic And Antibiotic Stewardship In Different Bacterial Infections
Procalcitonin (PCT), a protein that consists of 116 amino acids, is the peptide precursor of calcitonin, The final step in the synthesis of calcitonin is inhibited by cytokines and endotoxin released during bacterial infections; therefore, procalcitonin levels are selectively elevated in patients with bacterial infections. Because of the diverse etiologies of community-acquired pneumonia (CAP) and the limitations of current diagnostic modalities, serum procalcitonin levels have been proposed as a novel tool to guide antibiotic therapy. The clinical utility of serum procalcitonin (PCT) levels continues to manifest. Procalcitonin (PCT), has recently become of interest as a possible marker of the systemic inflammatory response to infection. Numerous studies abroad have proved its efficacy as a marker of critical illness. Fortunately no similar studies exist in Indian literature.The aim of this review is to summarize the current evidence for PCT in different bacterial infections and clinical settings, and to discuss the reliability of this marker when used with validated diagnostic algorithms.