Design Synthesis And Biological Evaluation Of Pyrazolyl-Thiazole Incorporated Coumarinyl Pharmacophore And Docking Studies
A novel series of substituted pyrazolyl-thiazole incorporated with coumarinyl pharmacaphore were designed and synthesized. The structure of title compounds were characterized by spectroscopic data IR, NMR, mass spectral data and elemental analysis. The compounds were evaluated for their anti-diabetic activity against Acarbose cell line and anti oxidant activity against pathogenic microbial strains. Molecular docking is the in silico technique which is used to extend the homology model for the new drug candidate. This field will reduce the number of synthetic compound in drug discovery research. The synthesized pyrazolyl-thiazole compounds showed a very good anti-diabetic activity. Thus, we continued to dock the ligand with enzyme like alpha amylase. Here, the synthesized compounds were docked with 2HR7 enzymes with the use molecular docking tools and the docking results are briefly explained. The various types of interactions amidst the compounds and amino acid residue of enzyme were reported.