Preventive Efficacy of Rabies Serum in Experiments on Rabbits and Dogs

Abstract

The results of the studies showed that the administration of rabies and dogs anti-rabies hyperimmune serum after 3.5.7 and 8 days after infection with street rabies virus, 100% of them protect against rabies, while all control animals that did not receive such serum got rabies for 13-15 days of experience. At the same time, the administration of experimental rabies hyperimmune serum to experimental animals 10 and 12 days after infection with the street rabies virus does not protect them from this disease. It was also established that these periods (10-12 days) were sufficient for complete reproduction of the street virus in the brain, and the anti-rabies antibodies found in hyperimmune serum were not able to put the already developed infectious process.