FORMULATION AND IN-VITRO EVALUATION OF ORO-DISPERSIBLE TABLET OF DABIGATRAN

Abstract

The aim of the study was to optimize the formulation of orodispersable tablets of dabigatran. It was prepared having direct compression method and evaluated for different types of superdisintegrants such as Debigatran- β-CD complex, SSG, CCS, CP, Mg stearate. at different concentrations. All the formulations were evaluated for effect of disintegrants on tablets as S1, S2, S3. Obtained result was satisfactory for each formulation but S3 was reported better result.  The idea optimize in this study helps to research about formulation processing variable on tablets properties. It could be concluded that all the formulations are suitable for development of ODTs Dabigtran.