“Avosose” Isolation and Structure Elucidation of Novel octasaccharide from Gaddi Sheep’s Milk

Abstract

Milk is a primary and rich source of nutrition in infants. This white liquid food produced by the mammary glands of mammals. After water carbohydrate is main constituent of milk. Early lactation milk which is known as colostrum, it contains different antibodies and protects new born from various diseases like tuberculosis, microbial infections etc. Milk acts as anti-fungal, anti-baterial, anti-inflammatory, anti-coagulant, anti-cancer etc. Keep in mind the earlier research on milk, Gaddi Sheep’s milk is collected from high altitude [Himalayan] region and isolate oligosaccharides by Kobata and Ginsberg method. Isolated oligosaccharide named as Avosose, it is a octasaccharide. Structure of Avosose are confirmed by Silica gel chromatography, HPLC and chemical degradation which further supported by NMR (1H, 13C, HSQC, HMBC, COSY, TOCSY etc.) and Mass Spectroscopy as-