Recollection of Odontogenic Keratocyst- A Benign Lesion with aggressive Behaviour

Abstract

Odontogenic keratocyst (OKC) is a benign but locally destructive lesion. The biological nature of odontogenic keratocyst has been a matter of discussion since  long time. Due to its aggressive behavior, there has been always controversies regarding the cystic or the neoplastic behavior of the lesion. Since the lesion behaves aggressively, has very high chances of recurrence, is associated with PTCH gene mutations and nevoid basal cell carcinoma syndrome, it becomes very important to know the factors associated with OKC which will determine the aggressive behavior of the lesion. Thus a review of the histopathological features, biological behaviour and a contemporary outline of molecular (growth factors, p53, PCNA and Ki-67, bcl-2) and genetic (PTCH, SHH) alterations associated with this neoplasm was done. These histological and molecular findings will further aid the clinician to plan appropriate surgical intervention and keep regular follow-ups to identify recurrences.